PKPD Post Doc

NHS

  • Bristol Area
  • £31,049-37,796 per year
  • Contract
  • Full-time
  • 17 hours ago
To lead new evaluations regarding pharmacokinetic and pharmacodynamic (PKPD) for pulmonary optimization within the PKPD laboratory (Research Microbiology Department).To work closely with the Consultant respiratory physician and Head Research Scientist in the PKPD lab to ensure the management of simulations is of a high quality and to take responsibility for :High quality dataMIC studiesTime Kill Curve evaluationsImmunoassay and liquid chromatographic assays, including the operation, maintenance and management of HPLC systems within the ARL laboratory.Development of PKPD modelsMethod development of respiratory agentsProviding specialist microbiology susceptibility and molecular testsThe role will also include assistance in North Bristol Trusts NIHR CRN Portfolio and other microbiology research projects. The post holder will be required to work alone and participate in regular out of hours workingMain duties of the jobPractical responsibilitiesImplement the setup and running and, quality assure the data generated from pharmacodynamic models as designed to investigate the interactions of antibiotics on bacteria in a research settingEnsure accurate data collection and analysis as appropriate using Excel and Word and specialist software such as Graph Pad Prism.Measurement, analysis and quality assure antimicrobial agents used in PK/PD studies by immunoassay, liquid chromatography or bio-assayPerform tests to assess the susceptibility of bacteria to antibiotics by both routine and specialist techniques, including disc methods, agar and broth dilution methods, E test, and antibiotic - antibiotic interaction studiesTo support the line manager in the delivery of Pharma, NBT and NIHR-CRN research projectsAbout usNorth Bristol NHS Trust employs over 12,000 staff providing healthcare to the residents of Bristol, South Gloucestershire and North Somerset from our award-winning hospital building at Southmead. We are the regional Major Trauma Centre, and an internationally recognised centre of excellence in a range of services and major specialities. Our vision is that by enabling our teams to be the best that they can be, we will provide exceptional healthcare, personally delivered.North Bristol NHS Trust values all people as individuals. We aim to be an anti-discriminatory organisation and are committed to building a team that represents a variety of backgrounds, perspectives, and skills. We welcome applicants from all underrepresented groups.DetailsDate posted03 September 2025Pay schemeAgenda for changeBandBand 5Salary£31,049 to £37,796 a year per annum (FTE) or pro-rata for part time rolesContractFixed termDuration24 monthsWorking patternFull-timeReference number339-CCS4947-CCCJob locationsSouthmead HospitalPathology science buildingBristolBS10 5NBJob descriptionJob responsibilitiesKnowledgeA relevant science degree, or post graduate degree with equivalent specialist experience1 year practical experience in PKPD in vitro modelling, MIC scienceisessential1 year practical and appropriate theoretical knowledge of analytical techniques including susceptibility testing; determination of resistance mechanisms and bacterial identification using molecular techniquesExperience working in a research team is essentialAble to maintain and demonstrate a high level of practical competence and willingness to undertake further training as requiredKnowledge of laboratory polices, codes of practice and professional guidelinesKnowledge of health and safety issues pertinent to laboratory workSkillsUnder the direction of the Lead Research Clinical Scientist -Organize the day to day running of the respiratory PKPD simulationsUndertake a range of diagnostic tests relevant to the area of workPresent data both written and oral including laboratory reportsPlan, prioritize, implement and evaluate own workload and workload for support teamTeach and supervise non-professionally qualified staff ( if required)Use NBT Clerical and IT skillsWork independently and be able to develop good relationships with colleagues, and external collaborators.Maintain and demonstrate a high level of practical competence and willingness to undertake further training as requiredFor further details / informal visits contact: Job descriptionJob responsibilitiesKnowledgeA relevant science degree, or post graduate degree with equivalent specialist experience1 year practical experience in PKPD in vitro modelling, MIC scienceisessential1 year practical and appropriate theoretical knowledge of analytical techniques including susceptibility testing; determination of resistance mechanisms and bacterial identification using molecular techniquesExperience working in a research team is essentialAble to maintain and demonstrate a high level of practical competence and willingness to undertake further training as requiredKnowledge of laboratory polices, codes of practice and professional guidelinesKnowledge of health and safety issues pertinent to laboratory workSkillsUnder the direction of the Lead Research Clinical Scientist -Organize the day to day running of the respiratory PKPD simulationsUndertake a range of diagnostic tests relevant to the area of workPresent data both written and oral including laboratory reportsPlan, prioritize, implement and evaluate own workload and workload for support teamTeach and supervise non-professionally qualified staff ( if required)Use NBT Clerical and IT skillsWork independently and be able to develop good relationships with colleagues, and external collaborators.Maintain and demonstrate a high level of practical competence and willingness to undertake further training as requiredFor further details / informal visits contact:Person SpecificationwrittenEssential
  • PKPD practical experience
  • Performed PhD studies
  • Microbiology practical experience
  • Experience of trouble shooting
Desirable
  • Training experience
  • Working as part as a team and independently
VerbalEssential
  • PKPD knowledge
Desirable
  • HPLC knowledge
Person SpecificationwrittenEssential
  • PKPD practical experience
  • Performed PhD studies
  • Microbiology practical experience
  • Experience of trouble shooting
Desirable
  • Training experience
  • Working as part as a team and independently
VerbalEssential
  • PKPD knowledge
Desirable
  • HPLC knowledge

NHS