Job Category: AcademicJob Description:Grade UE07: £41,064 - £48,822 per annum (pro rata if part time)Clinical Sciences / Institute for Regeneration and Repair / Centre for Inflammation ResearchFull-time: 35 hours per weekFixed Term: 3 yearsWe are looking for a Bioinformatician to study cellular responses to injury and ageing using integrated single-cell, spatial and proteomic technologies. The post will be based in the Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh with Professor David Ferenbach.This post is advertised as full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. We are also open to considering requests for hybrid working (on a non-contractual basis) that combines a mix of remote and regular on-campus working.The Opportunity:This fellowship forms part of an MRC-funded Senior Clinical Fellowship, based in the Institute for Regeneration and Repair - home to over 1000 research staff and students. Its focus is on the identification of novel pathways linking senescent epithelia to tissue fibrosis in human chronic kidney disease. The post holder will lead the computational identification and analysis of these pathways using spatial transcriptomic analysis of human kidney biopsies, and single-cell resolution analysis of renal cell populations obtained ex vivo / in vitro. Further work will explore the potential for these pathways to be targeted in vivo to promote senescent cell clearance and prevent senescent cell accumulation with ageing and tissue injury.Your skills and attributes for success:
A PhD, or near completion, in Mathematics, Physics, Computational Science, Genomics, Genetics, Computational Biology (or similar), and a passion for problem solving.
Understanding of single cell transcriptome and/or genome data analysis.
Proficiency in analysing NGS sequencing data and (RNA-seq, ATAC-seq, Chip-seq, single cell)
An understanding, experience and published outcomes from analysing and interpreting large datasets using at least one statistical package (e.g. R/SPLUS, SAS) and proficiency with scripting languages (R/Python) and Linux/Bash
Experience in the analysis of high-throughput biological datasets.
Click to view a copy of the full (opens new browser tab)As part of this application, you are required to submit a document of no more than one page detailing how you meet each of the essential criteria as outlined on the job description.As a valued member of our team you can expect:
A competitive salary
An exciting, positive, creative, challenging and rewarding place to work.
To be part of a diverse and vibrant international community
Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our
(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefitsChampioning equality, diversity and inclusionThe University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab).The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant. Please note if the role is offered on a part-time basis, it may result in sponsorship being dependant on a number of factors specific to the successful applicant or the role no longer meeting the Home Office's criteria for sponsorship.Key dates to noteThe closing date for applications is 24 September 2025.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.We anticipate that interviews will be held within 2-3 weeks of the advert closing date.About Us: As a world-leading research-intensive University, we are here to address tomorrow's greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.About the Team:The Centre for Inflammation Research (CIR; Director, Professor David Dockrell) leverages peer-reviewed interdisciplinary research programmes and focussed collaboration, to characterise mechanisms of acute and chronic inflammation. CIR aims to characterise what promotes health at the molecular level in order to prevent the harmful consequences of inflammation in clinical medicine. Effort is targeted at: inhibiting the initiation of inflammation by blocking specific molecular triggers and by modulating cellular and tissue responses resulting in organ dysfunction; finding new approaches to modulate established inflammatory responses to limit tissue injury; and promoting safe resolution of inflammation to restore healthy structure and function of tissue.The CIR has a broad interest in inflammatory disease in a range of tissues including in the lungs, kidney, liver, pancreas, bowel, bone, joints, skin, heart and brain. There is in-depth analysis of stimuli that induce or modify inflammation with detailed programmes considering the role of sex, development, auto-immunity, infection and other environmental influences. Importantly, the principles derived will have ready application to inflammatory and reparatory responses in virtually all physiological and pathological settings, including cancer and infection (not least COVID-19). Translation is aided by a commitment to novel diagnostic and imaging modalities and our proximity to patient groups and healthy volunteers in the Royal Infirmary, Edinburgh.Our research aims align closely with the vision of IRR and other centres within IRR, to promote human health through in-depth understanding of tissue regeneration and repair, while developing a multi-pronged translational programme to effect therapeutic innovation in this area. IRR is located on the BioQuarter Campus, Edinburgh.
